Over the past decade, the science related to developing and identifying "evidence-based practices and programs" has improved, however, the science related to implementing these programs with fidelity and good outcomes for consumers lag far behind. To this end, our intent is to describe the current state of the science of implementation, and identify what it will take to transmit innovative programs and practices to mental health, social services, juvenile justice, education, early childhood education, employment services, and substance abuse prevention and treatment. This monograph summarizes findings from the review of the research literature on implementation and proposes frameworks for understanding effective implementation processes. The results of this literature review and synthesis confirm that systematic implementation practices are essential to any national attempt to use the products of science - such as evidence-based programs - to improve the lives of its citizens.