Placental CpG Methylation of HPA-Axis Genes Is Associated With Cognitive Impairment at Age 10 Among Children Born Extremely Preterm

Meakin, C. J., Martin, E. M., Santos, H. P., Mokrova, I., Kuban, K., O'Shea, T. M., Joseph, R. M., Smeester, L., & Fry, R. C.
2018

Highlights

Placental CpG methylation in relation to cognition at age 10 was evaluated.

Ten HPA axis-associated genes were associated with cognitive function.

The transcriptional regulator MECP2 was enriched within the ten HPA axis genes.

Placental CpG methylation in the context of fetal development is discussed.

This study relates to the developmental origins of health and disease hypothesis.

Available here: Hormones and Behavior
Citation: Meakin, C. J., Martin, E. M., Santos, H. P., Mokrova, I., Kuban, K., O'Shea, T. M., . . . Fry, R. C. (2018). Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm. Hormones and Behavior, 101, 29-35.
DOI: 10.1016/j.yhbeh.2018.02.007