The significant investment in developing evidence-based practices and other innovations will be worthwhile if it helps further the education of students and benefit their families and communities. The State Implementation and Scaling-up of Evidence-based Practices (SISEP) Center helps states establish adequate capacity to carry out effective implementation, organization change, and system transformation strategies to maximize the academic achievement and behavioral health outcomes for students statewide. Working in close cooperation with state leaders and relevant TA Centers, SISEP provides the critical content and foundation for establishing a technology of large-scale, sustainable, high-fidelity implementation of effective educational practices. This manuscript will be developed as a means to disseminating strategies for states to deliberately and systematically develop and make effective use of an implementation infrastructure to accomplish educationally and socially significant outcomes for students statewide.