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Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Crowther, A., Smoski, M. J., Minkel, J., Moore, T., Gibbs, D., Petty, C., Bizzell, J., Schiller, C. E., Sideris, J., Carl, H., & Dichter, G. S.
2015

From the abstract: "In the present study, we investigated whether resting-state functional brain connectivity predicted response to Behavioral Activation Treatment for Depression, an empirically validated psychotherapy modality designed to increase engagement with rewarding stimuli and reduce avoidance behaviors. Twenty-three unmedicated outpatients with MDD and 20 matched nondepressed controls completed rs-fcMRI scans after which the MDD group received an average of 12 sessions of psychotherapy. The mean change in Beck Depression Inventory-II scores after psychotherapy was 12.04 points, a clinically meaningful response..."

Citation

Crowther, A., Smoski, M. J., Minkel, J., Moore, T., Gibbs, D., Petty, C., . . . Dichter, G. S. (2015). Resting-state connectivity predictors of response to psychotherapy in major depressive disorder. Neuropsychopharmacology, 40, 1659-1673.

DOI

10.1038/npp.2015.12