This brief explains how four important system design initiatives frequently promoted by state and local education agencies for school improvement can be implemented through an intentional system approach for a powerful, positive impact on student outcomes.  As technical assistance providers with expertise in four specific frameworks for educational system design and with great appreciation for one another, we suggest how a coordinated Stage-based Implementation process with embedded, systems-level critical Equity Inquiries at every stage can enable schools to establish Universal Design for Learning (UDL) principles and guidelines within a Multi-Tiered System of Support (MTSS) for a designed experience in instructional decision-making.